1.6M XNAS Volume
XNAS 24 Mar, 2025 1:57 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Dennis M. Lanfear | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.39 per share. | 20 Jan 2025 | 11,810 | 685,074 (0%) | 0% | 1.4 | 16,416 | Common Stock |
| Bryan J. McMichael | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.39 per share. | 20 Jan 2025 | 1,711 | 22,951 (0%) | 0% | 1.4 | 2,378 | Common Stock |
| Paul Reider | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.39 per share. | 20 Jan 2025 | 4,858 | 82,069 (0%) | 0% | 1.4 | 6,753 | Common Stock |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 575,000 | 575,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.66 per share. | 04 Jan 2025 | 11,810 | 696,884 (0%) | 0% | 1.7 | 19,605 | Common Stock |
| Bryan J. McMichael | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 160,000 | 160,000 | - | - | Stock Option (Right to Buy) | |
| Paul Reider | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.66 per share. | 03 Jan 2025 | 2,277 | 86,927 (0%) | 0% | 1.7 | 3,780 | Common Stock |
| Paul Reider | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 160,000 | 160,000 | - | - | Stock Option (Right to Buy) | |
| Paul Reider | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.61 per share. | 13 Dec 2024 | 2,073 | 89,204 (0%) | 0% | 1.6 | 3,338 | Common Stock |
| Bryan J. McMichael | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Aug 2024 | 75,000 | 75,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jul 2024 | 196,500 | 196,500 | - | - | Stock Option (Right to Buy) | |
| Paul Reider | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jul 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Georgia L. Erbez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 114,000 | 114,000 | - | - | Stock Option (Right to Buy) | |
| Rita A. Karachun | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 168,000 | 168,000 | - | - | Stock Option (Right to Buy) | |
| Mark D. Stolper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 112,000 | 112,000 | - | - | Stock Option (Right to Buy) | |
| Mats L. Wahlstrom | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 112,000 | 112,000 | - | - | Stock Option (Right to Buy) | |
| Kimberly J. Commins-Tzoumakas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 112,000 | 112,000 | - | - | Stock Option (Right to Buy) | |
| Lee N. Newcomer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 112,000 | 112,000 | - | - | Stock Option (Right to Buy) | |
| Charles Newton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 112,000 | 112,000 | - | - | Stock Option (Right to Buy) | |
| Jill O’Donnell-Tormey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 112,000 | 112,000 | - | - | Stock Option (Right to Buy) | |
| Michael Lee Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 112,000 | 112,000 | - | - | Stock Option (Right to Buy) | |
| Georgia L. Erbez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2024 | 54,000 | 54,000 | - | - | Stock Option (Right to Buy) | |
| Wahlstrom L. Mats | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Feb 2024 | 99,988 | 0 (0%) | 0% | 0 | Common Stock | |
| Wahlstrom L. Mats | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Feb 2024 | 99,988 | 99,988 (0%) | 0% | 0 | Common Stock | |
| Mats Wahlstrom L. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.67 per share. | 01 Feb 2024 | 44,991 | 99,988 (0%) | 0% | 1.7 | 75,000 | Common Stock |
| L. Wahlstrom Mats | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2024 | 14,997 | 0 | - | - | Stock Option (Right to Buy) | |
| Wahlstrom L. Mats | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.67 per share. | 01 Feb 2024 | 14,997 | 54,997 (0%) | 0% | 1.7 | 25,000 | Common Stock |
| Mats L. Wahlstrom | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2024 | 44,991 | 0 | - | - | Stock Option (Right to Buy) | |
| McMichael Bryan J. | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.44 per share. | 20 Jan 2024 | 1,707 | 22,972 (0%) | 0% | 2.4 | 4,165 | Common Stock |
| Paul Reider | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.44 per share. | 20 Jan 2024 | 4,854 | 81,277 (0%) | 0% | 2.4 | 11,844 | Common Stock |
| M. Dennis Lanfear | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.44 per share. | 20 Jan 2024 | 11,218 | 708,694 (1%) | 0% | 2.4 | 27,372 | Common Stock |
| Bryan McMichael J. | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.87 per share. | 07 Jan 2024 | 1,707 | 24,679 (0%) | 0% | 2.9 | 4,899 | Common Stock |
| Lanfear M. Dennis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.92 per share. | 04 Jan 2024 | 11,781 | 719,912 (1%) | 0% | 2.9 | 34,401 | Common Stock |
| Paul Reider | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.92 per share. | 04 Jan 2024 | 2,275 | 86,131 (0%) | 0% | 2.9 | 6,643 | Common Stock |
| Lanfear M. Dennis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 575,000 | 575,000 | - | - | Stock Option (Right to Buy) | |
| J. Bryan McMichael | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 125,000 | 125,000 | - | - | Stock Option (Right to Buy) | |
| Reider Paul | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 160,000 | 160,000 | - | - | Stock Option (Right to Buy) | |
| McDavid Stilwell | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.33 per share. | 31 Dec 2023 | 18,440 | 75,305 (0%) | 0% | 3.3 | 61,405 | Common Stock |
| Reider Paul | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.37 per share. | 13 Dec 2023 | 2,049 | 88,406 (0%) | 0% | 2.4 | 4,856 | Common Stock |
| Michael Lee Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2023 | 54,000 | 54,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 225,000 | 225,000 | - | - | Stock Option (Right to Buy) | |
| McDavid Stilwell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| Bryan J. McMichael | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Paul Reider | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| Mark D. Stolper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 38,250 | 38,250 | - | - | Stock Option (Right to Buy) | |
| Mats L. Wahlstrom | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 38,250 | 38,250 | - | - | Stock Option (Right to Buy) | |
| Kimberly J. Commins-Tzoumakas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 38,250 | 38,250 | - | - | Stock Option (Right to Buy) | |
| Lee N. Newcomer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 38,250 | 38,250 | - | - | Stock Option (Right to Buy) | |
| Charles Newton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 38,250 | 38,250 | - | - | Stock Option (Right to Buy) | |
| Jill O’Donnell-Tormey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 38,250 | 38,250 | - | - | Stock Option (Right to Buy) | |
| McDavid Stilwell | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.84 per share. | 01 Apr 2023 | 3,457 | 102,252 (0%) | 0% | 6.8 | 23,646 | Common Stock |
| Paul Reider | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.84 per share. | 01 Apr 2023 | 2,451 | 87,053 (0%) | 0% | 6.8 | 16,765 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.84 per share. | 31 Mar 2023 | 16,278 | 116,361 (0%) | 0% | 6.8 | 111,342 | Common Stock |
| Bryan J. McMichael | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Mar 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 86,250 | 654,853 (0%) | 0% | 0 | Common Stock | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 40,000 | 131,323 (0%) | 0% | 0 | Common Stock | |
| McDavid Stilwell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 40,000 | 104,243 (0%) | 0% | 0 | Common Stock | |
| Bryan J. McMichael | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 12,500 | 26,386 (0%) | 0% | 0 | Common Stock | |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.85 per share. | 10 Jan 2023 | 3,602 | 94,925 (0%) | 0% | 9.9 | 35,480 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.26 per share. | 10 Jan 2023 | 3,602 | 91,323 (0%) | 0% | 10.3 | 36,957 | Common Stock |
| Bryan J. McMichael | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.58 per share. | 07 Jan 2023 | 1,699 | 13,886 (0%) | 0% | 9.6 | 16,276 | Common Stock |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 402,500 | 402,500 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.87 per share. | 04 Jan 2023 | 10,905 | 568,603 (0%) | 0% | 9.9 | 107,632 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.87 per share. | 04 Jan 2023 | 5,437 | 98,527 (0%) | 0% | 9.9 | 53,663 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| McDavid Stilwell | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.87 per share. | 04 Jan 2023 | 5,437 | 64,243 (0%) | 0% | 9.9 | 53,663 | Common Stock |
| McDavid Stilwell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Bryan J. McMichael | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Dec 2022 | 4,000 | 432,684 (0%) | 0% | 0 | Common Stock | |
| Bryan J. McMichael | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Sep 2022 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Jill O’Donnell-Tormey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2022 | 54,000 | 54,000 | - | - | Stock Option (Right to Buy) | |
| Charles Newton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2022 | 54,000 | 54,000 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.85 per share. | 01 Apr 2022 | 3,458 | 103,963 (0%) | 0% | 12.8 | 44,435 | Common Stock |
| McDavid Stilwell | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.85 per share. | 01 Apr 2022 | 3,458 | 69,680 (0%) | 0% | 12.8 | 44,435 | Common Stock |
| Mats Wahlstrom | Director | Grant, award, or other acquisition of securities at price $ 11.64 per share. | 25 Feb 2022 | 10,006 | 10,006 (0%) | 0% | 11.6 | 116,433 | Common Stock |
| Mats Wahlstrom | Director | Grant, award, or other acquisition of securities at price $ 2.08 per share. | 25 Feb 2022 | 29,994 | 40,000 (0%) | 0% | 2.1 | 62,501 | Common Stock |
| Mats Wahlstrom | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2022 | 29,994 | 0 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.30 per share. | 10 Jan 2022 | 4,150 | 111,004 (0%) | 0% | 14.3 | 59,345 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.36 per share. | 10 Jan 2022 | 3,583 | 107,421 (0%) | 0% | 14.4 | 51,452 | Common Stock |
| James I. Healy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2022 | 27,000 | 27,000 | - | - | Stock Option (Right to Buy) | |
| Mark D. Stolper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2022 | 27,000 | 27,000 | - | - | Stock Option (Right to Buy) | |
| Mats Wahlstrom | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2022 | 27,000 | 27,000 | - | - | Stock Option (Right to Buy) | |
| Kimberly J. Commins-Tzoumakas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2022 | 27,000 | 27,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 402,500 | 402,500 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 86,250 | 579,508 (0%) | 0% | 0 | Common Stock | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 40,000 | 115,154 (0%) | 0% | 0 | Common Stock | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| McDavid Stilwell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 40,000 | 73,138 (0%) | 0% | 0 | Common Stock | |
| McDavid Stilwell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Nov 2021 | 10,000 | 436,684 (0%) | 0% | 0 | Common Stock | |
| McDavid Stilwell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 16.80 per share. | 15 Oct 2021 | 3,507 | 31,611 (0%) | 0% | 16.8 | 58,919 | Common Stock |
| James I. Healy | Director | Sale of securities on an exchange or to another person at price $ 17.17 per share. | 27 Sep 2021 | 48,329 | 286,076 (0%) | 0% | 17.2 | 829,809 | Common Stock, $0.0001 par value |
| James I. Healy | Director | Sale of securities on an exchange or to another person at price $ 16.12 per share. | 27 Sep 2021 | 286,076 | 0 (0%) | 0% | 16.1 | 4,611,545 | Common Stock, $0.0001 par value |
| James I. Healy | Director | Sale of securities on an exchange or to another person at price $ 18.06 per share. | 27 Sep 2021 | 100,150 | 334,405 (0%) | 0% | 18.1 | 1,808,709 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jul 2021 | 50,000 | 124,790 (0%) | 0% | 0 | Common Stock | |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jul 2021 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| McDavid Stilwell | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 13.42 per share. | 09 Jun 2021 | 3,700 | 35,118 (0%) | 0% | 13.4 | 49,668 | Common Stock |
| Dennis M. Lanfear | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.42 per share. | 06 Jun 2021 | 31,054 | 524,312 (0%) | 0% | 0.4 | 12,943 | Common Stock |
| Dennis M. Lanfear | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2021 | 31,054 | 0 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2021 | 300,000 | 31,054 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 13.56 per share. | 06 Jun 2021 | 31,054 | 493,258 (0%) | 0% | 13.6 | 421,229 | Common Stock |
| Dennis M. Lanfear | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.42 per share. | 06 Jun 2021 | 300,000 | 493,258 (0%) | 0% | 0.4 | 125,040 | Common Stock |
| Alan C. Mendelson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Mark D. Stolper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 20,000 | 73,402 (0%) | 0% | 0 | Common Stock | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 20,000 | 73,386 (0%) | 0% | 0 | Common Stock | |
| McDavid Stilwell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| McDavid Stilwell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 20,000 | 30,000 (0%) | 0% | 0 | Common Stock | |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.30 per share. | 09 Mar 2021 | 20,312 | 109,814 (0%) | 0% | 9.3 | 188,902 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 09 Mar 2021 | 57,812 | 167,626 (0%) | 0% | 10.1 | 581,011 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 09 Mar 2021 | 24,356 | 89,502 (0%) | 0% | 2.1 | 50,753 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2021 | 57,812 | 17,188 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2021 | 20,312 | 4,688 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2021 | 24,356 | 0 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 16.25 per share. | 09 Mar 2021 | 114,240 | 53,386 (0%) | 0% | 16.2 | 1,856,263 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.30 per share. | 05 Mar 2021 | 20,312 | 80,051 (0%) | 0% | 9.3 | 188,902 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 15.46 per share. | 05 Mar 2021 | 20,312 | 59,739 (0%) | 0% | 15.5 | 314,095 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 15.46 per share. | 05 Mar 2021 | 6,337 | 53,402 (0%) | 0% | 15.5 | 97,970 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2021 | 20,312 | 4,688 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 2,488 | 0 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.45 per share. | 17 Feb 2021 | 2,488 | 59,739 (0%) | 0% | 17.5 | 43,418 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Feb 2021 | 2,488 | 62,227 (0%) | 0% | 2.5 | 6,221 | Common Stock |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.55 per share. | 01 Feb 2021 | 7,402 | 61,295 (0%) | 0% | 21.5 | 159,513 | Common Stock |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 01 Feb 2021 | 7,402 | 68,697 (0%) | 0% | 10.0 | 74,390 | Common Stock |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2021 | 7,402 | 54,167 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2021 | 125,000 | 125,000 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2021 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 25 Jan 2021 | 40,000 | 107,439 (0%) | 0% | 10.1 | 402,000 | Common Stock |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jan 2021 | 40,000 | 61,569 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 25 Jan 2021 | 6,144 | 61,295 (0%) | 0% | 19 | 116,736 | Common Stock |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.10 per share. | 25 Jan 2021 | 40,000 | 67,439 (0%) | 0% | 20.1 | 804,000 | Common Stock |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2021 | 500,000 | 500,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.94 per share. | 19 Jan 2021 | 2,500 | 59,739 (0%) | 0% | 17.9 | 44,852 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jan 2021 | 2,500 | 2,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 19 Jan 2021 | 2,500 | 62,239 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 62,500 | 62,500 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 31,250 | 67,439 (0%) | 0% | 0 | Common Stock | |
| Mary T. Szela | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Samuel R. Nussbaum | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| V. Bryan Lawlis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Mats Wahlstrom | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 31,250 | 59,739 (0%) | 0% | 0 | Common Stock | |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 62,500 | 62,500 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 62,500 | 62,500 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 31,250 | 65,146 (0%) | 0% | 0 | Common Stock | |
| Kimberly J. Commins-Tzoumakas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.18 per share. | 10 Jan 2021 | 4,080 | 36,189 (0%) | 0% | 18.2 | 74,174 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.18 per share. | 10 Jan 2021 | 4,080 | 28,489 (0%) | 0% | 18.2 | 74,174 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.18 per share. | 10 Jan 2021 | 4,080 | 33,896 (0%) | 0% | 18.2 | 74,174 | Common Stock |
| Alan C. Mendelson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Mark D. Stolper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Dec 2020 | 2,500 | 35,069 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2020 | 2,500 | 4,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.51 per share. | 17 Dec 2020 | 2,500 | 32,569 (0%) | 0% | 17.5 | 43,780 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2020 | 30,000 | 41,982 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 09 Dec 2020 | 17,626 | 36,673 (0%) | 0% | 18.0 | 318,066 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 09 Dec 2020 | 17,626 | 54,299 (0%) | 0% | 2.1 | 36,729 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 18.24 per share. | 09 Dec 2020 | 49,512 | 36,673 (0%) | 0% | 18.2 | 903,084 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.08 per share. | 09 Dec 2020 | 30,000 | 86,185 (0%) | 0% | 2.1 | 62,514 | Common Stock |
| Vladimir Vexler | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2020 | 17,626 | 24,356 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.37 per share. | 07 Dec 2020 | 3,000 | 35,569 (0%) | 0% | 12.4 | 37,110 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2020 | 5,791 | 0 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2020 | 3,000 | 123,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.42 per share. | 07 Dec 2020 | 8,791 | 32,569 (0%) | 0% | 18.4 | 161,896 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 07 Dec 2020 | 5,791 | 41,360 (0%) | 0% | 12.7 | 73,546 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.85 per share. | 03 Dec 2020 | 49,000 | 32,569 (0%) | 0% | 18.9 | 923,694 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 03 Dec 2020 | 16,709 | 81,569 (0%) | 0% | 12.7 | 212,204 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.75 per share. | 03 Dec 2020 | 32,291 | 64,860 (0%) | 0% | 16.7 | 540,874 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.67 per share. | 03 Dec 2020 | 49,756 | 32,569 (0%) | 0% | 18.7 | 929,079 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.73 per share. | 03 Dec 2020 | 13,020 | 82,325 (0%) | 0% | 17.7 | 230,845 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.17 per share. | 03 Dec 2020 | 36,736 | 69,305 (0%) | 0% | 17.2 | 630,757 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2020 | 16,709 | 5,791 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2020 | 32,291 | 17,709 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2020 | 13,020 | 49,480 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2020 | 36,736 | 0 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Nov 2020 | 1,500 | 110,241 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.50 per share. | 17 Nov 2020 | 1,500 | 40,269 (0%) | 0% | 13.5 | 20,250 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 17.49 per share. | 17 Nov 2020 | 1,995 | 38,769 (0%) | 0% | 17.5 | 34,896 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Nov 2020 | 4,283 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Nov 2020 | 2,500 | 7,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 17 Nov 2020 | 4,283 | 32,569 (0%) | 0% | 18 | 77,094 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 17 Nov 2020 | 4,283 | 36,852 (0%) | 0% | 12.7 | 54,394 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.68 per share. | 17 Nov 2020 | 3,567 | 32,569 (0%) | 0% | 17.7 | 63,054 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.68 per share. | 17 Nov 2020 | 12,420 | 36,136 (0%) | 0% | 17.7 | 219,619 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.50 per share. | 17 Nov 2020 | 2,500 | 48,556 (0%) | 0% | 17.5 | 43,744 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Nov 2020 | 2,500 | 51,056 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Oct 2020 | 717 | 26,783 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Oct 2020 | 2,500 | 9,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.89 per share. | 19 Oct 2020 | 3,217 | 48,556 (0%) | 0% | 17.9 | 57,556 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 19 Oct 2020 | 717 | 51,773 (0%) | 0% | 12.7 | 9,106 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 19 Oct 2020 | 2,500 | 51,056 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 14 Oct 2020 | 6,144 | 40,423 (0%) | 0% | 19 | 116,736 | Common Stock, $0.0001 par value |
| James I. Healy | Director | Other type of transaction at price $ 0.00 per share. | 29 Sep 2020 | 213,546 | 434,555 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| James I. Healy | Director | Other type of transaction at price $ 0.00 per share. | 29 Sep 2020 | 950,000 | 0 (0%) | 1% | 0 | Common Stock, $0.0001 par value | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 17 Sep 2020 | 2,500 | 53,556 (0%) | 0% | 12.7 | 31,750 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2020 | 2,500 | 27,500 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2020 | 2,500 | 12,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.84 per share. | 17 Sep 2020 | 5,000 | 48,556 (0%) | 0% | 18.8 | 94,216 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Sep 2020 | 2,500 | 51,056 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| James I. Healy | Director | Other type of transaction at price $ 0.00 per share. | 28 Aug 2020 | 221,009 | 221,009 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| James I. Healy | Director | Other type of transaction at price $ 0.00 per share. | 28 Aug 2020 | 983,221 | 950,000 (1%) | 1% | 0 | Common Stock, $0.0001 par value | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Aug 2020 | 2,500 | 51,056 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 2,500 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 2,500 | 14,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.37 per share. | 17 Aug 2020 | 5,000 | 48,556 (0%) | 0% | 19.4 | 96,851 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 17 Aug 2020 | 2,500 | 53,556 (0%) | 0% | 12.7 | 31,750 | Common Stock |
| Kimberly J. Commins-Tzoumakas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jul 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 17 Jul 2020 | 12,500 | 63,556 (0%) | 0% | 12.7 | 158,750 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2020 | 12,500 | 32,500 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2020 | 2,500 | 17,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.25 per share. | 17 Jul 2020 | 15,000 | 48,556 (0%) | 0% | 18.2 | 273,687 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Jul 2020 | 2,500 | 51,056 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| Dennis M. Lanfear | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2020 | 29,994 | 0 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.01 per share. | 01 Jul 2020 | 29,994 | 193,258 (0%) | 0% | 0.0 | 249 | Common Stock, $0.0001 par value |
| Mary T. Szela | Director | Sale of securities on an exchange or to another person at price $ 17.58 per share. | 22 Jun 2020 | 54,997 | 0 (0%) | 0% | 17.6 | 966,759 | Common Stock, $0.0001 par value |
| Mary T. Szela | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 22 Jun 2020 | 14,997 | 14,997 (0%) | 0% | 2.5 | 37,500 | Common Stock, $0.0001 par value |
| Mary T. Szela | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 22 Jun 2020 | 20,000 | 34,997 (0%) | 0% | 10.1 | 201,000 | Common Stock, $0.0001 par value |
| Mary T. Szela | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.37 per share. | 22 Jun 2020 | 20,000 | 54,997 (0%) | 0% | 12.4 | 247,400 | Common Stock, $0.0001 par value |
| Mary T. Szela | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2020 | 14,997 | 0 | - | - | Stock Option (Right to Buy) | |
| Mary T. Szela | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2020 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Mary T. Szela | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2020 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Mats Wahlstrom | Director | Sale of securities on an exchange or to another person at price $ 17.15 per share. | 17 Jun 2020 | 200,000 | 0 (0%) | 0% | 17.2 | 3,430,020 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2020 | 2,500 | 19,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.22 per share. | 17 Jun 2020 | 2,500 | 48,556 (0%) | 0% | 17.2 | 43,050 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Jun 2020 | 2,500 | 51,056 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 17.66 per share. | 20 May 2020 | 1,278 | 46,567 (0%) | 0% | 17.7 | 22,569 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 18 May 2020 | 2,500 | 51,056 (0%) | 0% | 2.5 | 6,251 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 May 2020 | 2,500 | 22,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.17 per share. | 18 May 2020 | 2,500 | 48,556 (0%) | 0% | 17.2 | 42,925 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.17 per share. | 18 May 2020 | 593 | 48,556 (0%) | 0% | 17.2 | 10,182 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 15.57 per share. | 17 Apr 2020 | 5,000 | 52,996 (0%) | 0% | 15.6 | 77,850 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2020 | 5,000 | 24,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 17 Apr 2020 | 5,150 | 47,846 (0%) | 0% | 17 | 87,550 | Common Stock |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Apr 2020 | 5,000 | 57,996 (0%) | 0% | 2.5 | 12,503 | Common Stock |
| Mats Wahlstrom | Director | Sale of securities on an exchange or to another person at price $ 20.89 per share. | 03 Mar 2020 | 4,222 | 200,000 (0%) | 0% | 20.9 | 88,215 | Common Stock, $0.0001 par value |
| Mats Wahlstrom | Director | Sale of securities on an exchange or to another person at price $ 20.09 per share. | 03 Mar 2020 | 113,844 | 204,222 (0%) | 0% | 20.1 | 2,287,194 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.33 per share. | 19 Feb 2020 | 3,159 | 46,841 (0%) | 0% | 22.3 | 70,552 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Feb 2020 | 3,159 | 101,569 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 19 Feb 2020 | 3,159 | 50,000 (0%) | 0% | 10.1 | 31,748 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 21.64 per share. | 18 Feb 2020 | 2,500 | 57,996 (0%) | 0% | 21.6 | 54,100 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2020 | 2,500 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2020 | 2,500 | 29,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 21.64 per share. | 18 Feb 2020 | 5,000 | 52,996 (0%) | 0% | 21.6 | 108,190 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 21.64 per share. | 18 Feb 2020 | 2,500 | 57,996 (0%) | 0% | 21.6 | 54,100 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 18 Feb 2020 | 2,500 | 60,496 (0%) | 0% | 12.7 | 31,750 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 18 Feb 2020 | 2,500 | 60,496 (0%) | 0% | 2.5 | 6,251 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.57 per share. | 17 Jan 2020 | 2,500 | 62,996 (0%) | 0% | 19.6 | 48,921 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2020 | 2,500 | 47,500 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2020 | 2,500 | 32,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.69 per share. | 17 Jan 2020 | 2,500 | 57,996 (0%) | 0% | 19.7 | 49,213 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 17 Jan 2020 | 2,500 | 60,496 (0%) | 0% | 12.7 | 31,750 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.56 per share. | 17 Jan 2020 | 5,000 | 57,996 (0%) | 0% | 19.6 | 97,796 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 17 Jan 2020 | 2,500 | 65,496 (0%) | 0% | 2.5 | 6,251 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2020 | 6,318 | 104,728 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.08 per share. | 15 Jan 2020 | 2,798 | 46,841 (0%) | 0% | 20.1 | 56,186 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.67 per share. | 15 Jan 2020 | 3,520 | 49,639 (0%) | 0% | 19.7 | 69,238 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 15 Jan 2020 | 6,318 | 53,159 (0%) | 0% | 10.1 | 63,496 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 19,365 | 22,668 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 62,500 | 62,500 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 31,250 | 46,841 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.73 per share. | 10 Jan 2020 | 7,077 | 15,591 (0%) | 0% | 17.7 | 125,475 | Common Stock, $0.0001 par value |
| Mary T. Szela | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Samuel R. Nussbaum | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| V. Bryan Lawlis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 59,763 | 184,780 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Dennis M. Lanfear | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 500,000 | 500,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.73 per share. | 10 Jan 2020 | 21,516 | 163,264 (0%) | 0% | 17.7 | 381,479 | Common Stock, $0.0001 par value |
| Mats Wahlstrom | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Christos Richards | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Ali J. Satvat | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.73 per share. | 10 Jan 2020 | 7,146 | 31,746 (0%) | 0% | 17.7 | 126,699 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 62,500 | 62,500 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 31,250 | 62,996 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 19,566 | 38,892 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 8,900 | 28,412 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 62,500 | 62,500 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 31,250 | 56,185 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.73 per share. | 10 Jan 2020 | 3,477 | 24,935 (0%) | 0% | 17.7 | 61,647 | Common Stock, $0.0001 par value |
| James I. Healy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.37 per share. | 09 Jan 2020 | 20,000 | 70,086 (0%) | 0% | 12.4 | 247,400 | Common Stock, $0.0001 par value |
| James I. Healy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jan 2020 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jan 2020 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jan 2020 | 29,994 | 0 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.67 per share. | 09 Jan 2020 | 29,994 | 30,086 (0%) | 0% | 1.7 | 50,000 | Common Stock, $0.0001 par value |
| James I. Healy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 09 Jan 2020 | 20,000 | 50,086 (0%) | 0% | 10.1 | 201,000 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2019 | 2,500 | 34,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.69 per share. | 16 Dec 2019 | 2,500 | 19,326 (0%) | 0% | 18.7 | 46,725 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 16 Dec 2019 | 2,500 | 21,826 (0%) | 0% | 2.5 | 6,251 | Common Stock, $0.0001 par value |
| Dennis M. Lanfear | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 18.56 per share. | 21 Nov 2019 | 12,500 | 446,684 (0%) | 0% | 18.6 | 231,960 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 20 Nov 2019 | 3,159 | 6,462 (0%) | 0% | 10.1 | 31,748 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Nov 2019 | 3,159 | 111,046 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.59 per share. | 20 Nov 2019 | 3,159 | 3,303 (0%) | 0% | 19.6 | 61,872 | Common Stock, $0.0001 par value |
| Dennis M. Lanfear | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 20 Nov 2019 | 825,000 | 459,184 (0%) | 1% | 18 | 14,850,000 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.88 per share. | 18 Nov 2019 | 3,112 | 3,303 (0%) | 0% | 18.9 | 58,757 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 14 Nov 2019 | 2,500 | 21,810 (0%) | 0% | 2.5 | 6,251 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Nov 2019 | 2,500 | 37,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.26 per share. | 14 Nov 2019 | 2,500 | 19,310 (0%) | 0% | 19.3 | 48,150 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.02 per share. | 18 Oct 2019 | 1,388 | 6,385 (0%) | 0% | 19.0 | 26,400 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 16 Oct 2019 | 3,159 | 10,932 (0%) | 0% | 10.1 | 31,748 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Oct 2019 | 3,159 | 114,205 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 16 Oct 2019 | 3,159 | 7,773 (0%) | 0% | 19 | 60,021 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 14 Oct 2019 | 2,500 | 21,810 (0%) | 0% | 2.5 | 6,251 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2019 | 2,500 | 39,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.40 per share. | 14 Oct 2019 | 2,500 | 19,310 (0%) | 0% | 18.4 | 46,000 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.78 per share. | 23 Sep 2019 | 740 | 7,773 (0%) | 0% | 21.8 | 16,117 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 18 Sep 2019 | 3,159 | 11,672 (0%) | 0% | 10.1 | 31,748 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2019 | 3,159 | 117,364 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.44 per share. | 18 Sep 2019 | 3,159 | 8,513 (0%) | 0% | 20.4 | 64,560 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 20.03 per share. | 16 Sep 2019 | 2,500 | 19,310 (0%) | 0% | 20.0 | 50,075 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2019 | 2,500 | 42,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 16 Sep 2019 | 2,500 | 21,810 (0%) | 0% | 2.5 | 6,251 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 21 Aug 2019 | 6,318 | 14,831 (0%) | 0% | 10.1 | 63,496 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2019 | 6,318 | 120,523 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.75 per share. | 21 Aug 2019 | 6,058 | 8,513 (0%) | 0% | 21.8 | 131,766 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.73 per share. | 21 Aug 2019 | 260 | 14,571 (0%) | 0% | 20.7 | 5,389 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.04 per share. | 19 Aug 2019 | 3,000 | 8,513 (0%) | 0% | 19.0 | 57,120 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 14 Aug 2019 | 2,500 | 19,310 (0%) | 0% | 19 | 47,500 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Aug 2019 | 2,500 | 44,988 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 14 Aug 2019 | 2,500 | 21,810 (0%) | 0% | 2.5 | 6,251 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.20 per share. | 15 Jul 2019 | 2,500 | 19,310 (0%) | 0% | 19.2 | 48,000 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2019 | 2,500 | 47,488 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.50 per share. | 15 Jul 2019 | 2,500 | 21,810 (0%) | 0% | 2.5 | 6,251 | Common Stock, $0.0001 par value |
| James I. Healy | None | Sale of securities on an exchange or to another person at price $ 22.05 per share. | 28 Jun 2019 | 200,000 | 2,093,221 (2%) | 0% | 22.1 | 4,410,000 | Common Stock, $0.0001 par value |
| James I. Healy | None | Sale of securities on an exchange or to another person at price $ 22.61 per share. | 28 Jun 2019 | 160,000 | 1,933,221 (2%) | 0% | 22.6 | 3,617,600 | Common Stock, $0.0001 par value |
| James I. Healy | None | Sale of securities on an exchange or to another person at price $ 21.37 per share. | 20 Jun 2019 | 317,130 | 2,293,221 (3%) | 0% | 21.4 | 6,777,068 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.81 per share. | 18 Jun 2019 | 100 | 11,513 (0%) | 0% | 20.8 | 2,081 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.32 per share. | 18 Jun 2019 | 3,059 | 11,613 (0%) | 0% | 20.3 | 62,166 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.05 per share. | 18 Jun 2019 | 3,159 | 14,672 (0%) | 0% | 10.1 | 31,748 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.31 per share. | 18 Jun 2019 | 3,000 | 12,180 (0%) | 0% | 19.3 | 57,926 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 18 Jun 2019 | 667 | 11,513 (0%) | 0% | 20 | 13,340 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jun 2019 | 3,159 | 126,841 | - | - | Stock Option (Right to Buy) | |
| Mats Wahlstrom | None | Other type of transaction at price $ 0.00 per share. | 31 May 2019 | 98,152 | 318,066 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Mats Wahlstrom | None | Other type of transaction at price $ 0.00 per share. | 31 May 2019 | 178,528 | 0 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Dennis M. Lanfear | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 19.49 per share. | 30 May 2019 | 32,398 | 1,284,184 (1%) | 0% | 19.5 | 631,282 | Common Stock, $0.0001 par value |
| James I. Healy | None | Sale of securities on an exchange or to another person at price $ 20.69 per share. | 22 May 2019 | 257,870 | 2,610,351 (3%) | 0% | 20.7 | 5,335,330 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.92 per share. | 20 Mar 2019 | 3,000 | 13,185 (0%) | 0% | 14.9 | 44,762 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.37 per share. | 11 Jan 2019 | 6,297 | 16,185 (0%) | 0% | 12.4 | 77,894 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 16,685 | 22,482 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 126,000 | 126,000 | - | - | Stock Option (Right to Buy) | |
| Mary T. Szela | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Samuel R. Nussbaum | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| V. Bryan Lawlis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 450,000 | 450,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 50,265 | 142,884 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Dennis M. Lanfear | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.37 per share. | 11 Jan 2019 | 17,867 | 125,017 (0%) | 0% | 12.4 | 221,015 | Common Stock, $0.0001 par value |
| Mats Wahlstrom | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Christos Richards | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Ali J. Satvat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.37 per share. | 11 Jan 2019 | 6,404 | 17,295 (0%) | 0% | 12.4 | 79,217 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 16,997 | 23,699 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 126,000 | 126,000 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 15,562 | 23,390 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Vladimir Vexler | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.37 per share. | 11 Jan 2019 | 5,916 | 17,474 (0%) | 0% | 12.4 | 73,181 | Common Stock, $0.0001 par value |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2019 | 126,000 | 126,000 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Nov 2018 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Vladimir Vexler | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Nov 2018 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Sep 2018 | 740 | 111,741 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.50 per share. | 21 Sep 2018 | 740 | 4,519 (0%) | 0% | 13.5 | 9,990 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2018 | 1,760 | 82,941 | - | - | Stock Option (right to buy) | |
| Barbara K. Finck | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.58 per share. | 10 Sep 2018 | 1,760 | 37,043 (0%) | 0% | 18.6 | 32,699 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share. | 10 Sep 2018 | 1,760 | 38,803 (0%) | 0% | 1.4 | 2,499 | Common Stock, $0.0001 par value |
| James I. Healy | None | Sale of securities on an exchange or to another person at price $ 20.50 per share. | 29 Aug 2018 | 25,000 | 2,868,221 (4%) | 0% | 20.5 | 512,500 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share. | 13 Aug 2018 | 1,760 | 38,803 (0%) | 0% | 1.4 | 2,499 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 19.02 per share. | 13 Aug 2018 | 1,760 | 37,043 (0%) | 0% | 19.0 | 33,480 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2018 | 1,760 | 84,701 | - | - | Stock Option (right to buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.56 per share. | 23 Jul 2018 | 9,291 | 3,779 (0%) | 0% | 18.6 | 172,472 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share. | 09 Jul 2018 | 500 | 37,543 (0%) | 0% | 1.4 | 710 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2018 | 500 | 87,721 | - | - | Stock Option (right to buy) | |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2018 | 1,260 | 86,461 | - | - | Stock Option(right to buy) | |
| Barbara K. Finck | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 15.03 per share. | 09 Jul 2018 | 500 | 37,043 (0%) | 0% | 15.0 | 7,515 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share. | 09 Jul 2018 | 1,260 | 38,303 (0%) | 0% | 1.4 | 1,789 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 09 Jul 2018 | 1,260 | 37,043 (0%) | 0% | 15 | 18,900 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share. | 18 Jun 2018 | 1,760 | 38,803 (0%) | 0% | 1.4 | 2,499 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 18 Jun 2018 | 1,760 | 37,043 (0%) | 0% | 15 | 26,400 | Common Stock, $0.0001 par value |
| Barbara K. Finck | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jun 2018 | 1,760 | 88,221 | - | - | Stock Option (right to buy) | |
| Dennis M. Lanfear | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 16.26 per share. | 16 May 2018 | 20,984 | 1,316,582 (2%) | 0% | 16.3 | 341,265 | Common Stock, $0.0001 par value |
| Vincent R. Anicetti | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2018 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Samuel R. Nussbaum | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2018 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Vincent R. Anicetti | Chief, Quality & Compliance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2018 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 130,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Mary T. Szela | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| V. Bryan Lawlis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 400,000 | 400,000 | - | - | Stock Option (Right to Buy) | |
| Mats Wahlstrom | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Barbara K. Finck | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 130,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Peter K. Watler | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Christos Richards | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Ali J. Satvat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| August J. Troendle | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2017 | 6,966 | 9,958 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Dennis M. Lanfear | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2017 | 20,984 | 92,619 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Barbara K. Finck | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2017 | 7,545 | 34,336 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2017 | 809 | 50,460 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2017 | 5,900 | 5,900 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 15.02 per share. | 08 Aug 2017 | 17,535 | 49,651 (0%) | 0% | 15.0 | 263,300 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2017 | 67,000 | 67,000 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2017 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Barbara K. Finck | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2017 | 67,000 | 67,000 | - | - | Stock Option (Right to Buy) | |
| Peter K. Watler | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2017 | 67,000 | 67,000 | - | - | Stock Option (Right to Buy) | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 05 Jul 2017 | 600 | 67,186 (0%) | 0% | 15 | 9,000 | Common Stock, $0.0001 par value |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.98 per share. | 01 Jun 2017 | 1,732 | 67,786 (0%) | 0% | 21.0 | 36,342 | Common Stock, $0.0001 par value |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.20 per share. | 01 Jun 2017 | 9,601 | 69,518 (0%) | 0% | 20.2 | 193,950 | Common Stock, $0.0001 par value |
| Mary T. Szela | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| V. Bryan Lawlis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Mats Wahlstrom | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Mats Wahlstrom | None | Other type of transaction at price $ 0.00 per share. | 17 May 2017 | 200,000 | 378,528 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Mats Wahlstrom | None | Other type of transaction at price $ 0.00 per share. | 17 May 2017 | 109,957 | 109,957 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Mats Wahlstrom | None | Other type of transaction at price $ 0.00 per share. | 17 May 2017 | 200,000 | 178,528 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Mats Wahlstrom | None | Other type of transaction at price $ 0.00 per share. | 17 May 2017 | 109,957 | 219,914 (0%) | 0% | 0 | Common Stock, $0.0001 par value | |
| Christos Richards | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Ali J. Satvat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| August J. Troendle | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 01 May 2017 | 11,333 | 79,119 (0%) | 0% | 20.0 | 226,626 | Common Stock, $0.0001 par value |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.73 per share. | 03 Apr 2017 | 11,333 | 90,452 (0%) | 0% | 20.7 | 234,985 | Common Stock, $0.0001 par value |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 24.19 per share. | 01 Mar 2017 | 11,333 | 101,785 (0%) | 0% | 24.2 | 274,171 | Common Stock, $0.0001 par value |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.37 per share. | 01 Feb 2017 | 11,333 | 113,118 (0%) | 0% | 27.4 | 310,155 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jan 2017 | 3,900 | 112,481 | - | - | Stock Option (right to buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.00 per share. | 25 Jan 2017 | 3,900 | 2,992 (0%) | 0% | 27 | 105,300 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.50 per share. | 25 Jan 2017 | 3,900 | 6,892 (0%) | 0% | 13.5 | 52,650 | Common Stock, $0.0001 par value |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.60 per share. | 03 Jan 2017 | 683 | 124,451 (0%) | 0% | 28.6 | 19,536 | Common Stock, $0.0001 par value |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.90 per share. | 03 Jan 2017 | 10,650 | 125,134 (0%) | 0% | 27.9 | 297,186 | Common Stock, $0.0001 par value |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2016 | 3,900 | 117,048 | - | - | Stock Option (right to buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2016 | 667 | 2,992 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Dec 2016 | 3,900 | 2,325 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2016 | 3,900 | 6,225 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2016 | 667 | 116,381 | - | - | Stock Option (right to buy) | |
| Mats Wahlstrom | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 07 Dec 2016 | 7,393 | 46,190 | - | - | Common Stock, $0.0001 par value | |
| Mats Wahlstrom | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 07 Dec 2016 | 46,190 | 0 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Dec 2016 | 3,200 | 143,917 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Dec 2016 | 8,133 | 135,784 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 18 Nov 2016 | 3,900 | 2,325 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2016 | 3,900 | 6,225 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2016 | 3,900 | 120,948 | - | - | Stock Option (right to buy) | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Nov 2016 | 11,333 | 147,117 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 21 Oct 2016 | 3,900 | 2,325 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2016 | 3,900 | 6,225 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2016 | 3,900 | 124,848 | - | - | Stock Option (right to buy) | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Oct 2016 | 3,237 | 158,450 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Oct 2016 | 8,096 | 161,687 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Sep 2016 | 3,900 | 128,748 | - | - | Stock Option (right to buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Sep 2016 | 3,900 | 6,225 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 26 Sep 2016 | 3,900 | 2,325 | - | - | Common Stock, $0.0001 par value | |
| Dennis M. Lanfear | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Sep 2016 | 50 | 1,337,566 | - | - | Common Stock, $0.0001 par value | |
| Dennis M. Lanfear | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Sep 2016 | 4,010 | 1,337,616 | - | - | Common Stock, $0.0001 par value | |
| Dennis M. Lanfear | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Sep 2016 | 2,900 | 1,341,626 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Sep 2016 | 16,999 | 169,783 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 08 Aug 2016 | 40,000 | 0 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2016 | 40,000 | 48,503 | - | - | Stock Option (right to buy) | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2016 | 15,621 | 15,621 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2016 | 40,000 | 40,000 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2016 | 15,621 | 14,373 | - | - | Stock Option (right to buy) | |
| Peter K. Watler | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 08 Aug 2016 | 15,621 | 0 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Aug 2016 | 11,333 | 186,782 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 21 Jul 2016 | 700 | 0 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2016 | 3,991 | 88,503 | - | - | Stock Option (right to buy) | |
| Peter K. Watler | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 21 Jul 2016 | 3,291 | 700 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2016 | 3,991 | 3,991 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2016 | 23,741 | 16,247 | - | - | Stock Option (right to buy) | |
| Peter K. Watler | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Jul 2016 | 23,741 | 0 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2016 | 50,000 | 50,000 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2016 | 50,000 | 92,494 | - | - | Stock Option (right to buy) | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2016 | 23,741 | 23,741 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Jul 2016 | 50,000 | 0 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jul 2016 | 43,495 | 43,495 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 11 Jul 2016 | 43,495 | 0 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jul 2016 | 43,495 | 0 | - | - | Stock Option (right to buy) | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2016 | 1,925 | 2,325 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2016 | 1,925 | 132,648 | - | - | Stock Option (Right to Buy) | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jul 2016 | 4,250 | 198,115 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jun 2016 | 4,250 | 202,365 | - | - | Common Stock, $0.0001 par value | |
| V. Bryan Lawlis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| James I. Healy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Mary T. Szela | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Mats Wahlstrom | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Christos Richards | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Ali J. Satvat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| August J. Troendle | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2016 | 12,000 | 43,495 | - | - | Stock Option(right to buy) | |
| Peter K. Watler | Chief Technical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2016 | 12,000 | 12,000 | - | - | Common Stock, $0.0001 par value | |
| Peter K. Watler | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 17 May 2016 | 12,000 | 0 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2016 | 78,472 | 78,472 | - | - | Stock Option (Right to Buy) | |
| Dennis M. Lanfear | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2016 | 323,889 | 323,889 | - | - | Stock Option (Right to Buy) | |
| Barbara K. Finck | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2016 | 78,472 | 78,472 | - | - | Stock Option (Right to Buy) | |
| Alan C. Herman | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2016 | 69,236 | 69,236 | - | - | Stock Option (Right to Buy) | |
| Peter K. Watler | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2016 | 78,472 | 78,472 | - | - | Stock Option (Right to Buy) | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 May 2016 | 3,698 | 207,167 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 May 2016 | 552 | 206,615 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Apr 2016 | 977 | 210,865 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Apr 2016 | 3,273 | 211,842 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Mar 2016 | 400 | 400 | - | - | Common Stock, $0.0001 par value | |
| Jean-Frederic Viret | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Mar 2016 | 400 | 134,573 | - | - | Stock Option (Right to Buy) | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Mar 2016 | 6,015 | 215,115 | - | - | Common Stock, $0.0001 par value | |
| Alan C. Herman | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Mar 2016 | 485 | 221,130 | - | - | Common Stock, $0.0001 par value | |
| Mats Wahlstrom | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Feb 2016 | 1,000,000 | 1,000,000 | - | - | 8.2% Senior Convertible Notes due 2022 | |
| August J. Troendle | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2016 | 8,124 | 29,994 | - | - | Common Stock, $0.0001 par value | |
| August J. Troendle | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2016 | 8,124 | 0 | - | - | Stock Option (Right to Buy) |